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  • Title: Effect of vitamin A deficiency on the level of glutathione and glutathione S-transferase activity in rat colon and liver.
    Author: Gupta MP, Dogra SC, Khanduja KL, Sharma RR.
    Journal: Acta Vitaminol Enzymol; 1983; 5(3):141-5. PubMed ID: 6650300.
    Abstract:
    The effect of vitamin A status on colon and liver glutathione content and the activity of glutathione S-transferase was studied in rats. Animals were fed diets with or without vitamin A for 4-5 weeks. There was no difference in the weight gains of control and deficient animals. Hepatic and colonic level of vitamin A was significantly reduced in vitamin A deficient animals. Hepatic glutathione content was below control values (31%); whereas activity of glutathione S-transferase was enhanced in deficient animals (41.2%). Contrary to this, colon glutathione S-transferase activity was significantly reduced (40.7%) and glutathione content remained unchanged in vitamin A deficiency.
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