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  • Title: Use of midazolam and buprenorphine in combination anaesthesia.
    Author: Sjövall S.
    Journal: Ann Clin Res; 1983 Aug; 15(4):151-5. PubMed ID: 6651208.
    Abstract:
    In this comparative study in 102 female patients, midazolam or thiopentone was used as the sleep-inducing component in combination anaesthesia. During anaesthesia, three different analgesics: fentanyl, oxycodone and buprenorphine were tested. The sleep-inducing effect of midazolam was clearly slower in onset than that of thiopentone, but in other respects midazolam was a satisfactory inducing agent for general anaesthesia. Patients receiving midazolam and/or buprenorphine needed an additional dose of muscle relaxant less often than those receiving thiopentone and fentanyl or oxycodone. Buprenorphine produced a long postoperative analgesia lasting up to 10 hours, but these patients were also postoperatively drowsier, which gave a lower postanesthetic recovery score.
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