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  • Title: Midtrimester intra-aminotic administration of prostaglandin F2alpha in combination with an hyperosmolar urea solution: effect upon plasma levels of estradiol, progesterone, and human placental lactogen (HPL).
    Author: Sher G, Katz M.
    Journal: Acta Obstet Gynecol Scand; 1978; 57(3):223-5. PubMed ID: 665164.
    Abstract:
    A study was undertaken in order to investigate the clinical observation that patients who underwent midtrimester abortion using intra-amniotic PG F2alpha in combination with hyperosmolar urea, always aborted a dead fetus. Ten Caucasian primigravidae, aged between 16 and 22 years old and whose pregnancies ranged between 14 and 23 weeks in duration, were studied. The patients were randomly divided into two equal groups. The one group received urea and PG F2alpha intra-amniotically whereas the other received PG F2alpha alone. Blood was drawn for measurement of plasma estradiol, progesterone and human placental lactogen (HPL) prior to injection of the abortifacients and at regular intervals thereafter for a period of 120 min. The five patients who received the combination regime of treatment (urea + PG F2alpha) showed a rapid decline in the plasma concentrations of these hormones and induction of abortion was followed by fetal death within 35 min in all cases. In contrast, the five patients who received intra-amniotic PG F2alpha alone, did not (with a single exception), demonstrate this rapid decline in the plasma concentrations of the placental hormones measured. Also with the same single exception, these fetuses, although stillborn, were alive two hours after inducing abortion. A study was undertaken in order to investigate the clinical observation that patients who underwent midtrimester abortion using intraamniotic prostaglandin F2 alpha (PGF2 alpha) in combination with hyperosmolar urea, always aborted a dead fetus. 10 Caucasian primigravidae, aged between 16-22 years and whose pregnancies ranged between 14-23 weeks in duration, were studied. The patients were randomly divided into 2 equal groups. The 1 group received urea and PGF2 alpha intraamniotically whereas the other received PGF2 alpha alone. Blood was drawn for measurement of plasma estradiol, progesterone, and HPL prior to injection of the abortifacients and at regular intervals thereafter for a period of 120 minutes. The 5 patients who received the combination regime of treatment (urea plus PGF2 alpha) showed a rapid decline in the plasma concentrations of these hormones and induction of abortion was followed by fetal death within 35 minutes in all cases. In contrast, the 5 patients who received intraamniotic PGF2 alpha alone, did not (with a single exception), demonstrate this rapid decline in the plasma concentrations of the placental hormones measured. Also with the same single exception, these fetuses, although stillborn, were alive 2 hours after inducing abortion.
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