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  • Title: Identification of the insulin receptor in plasma membranes of Ehrlich ascites carcinoma cells by photoaffinity labeling.
    Author: Böhmer FD, Kurtskhalia TV, Grosse R, Girshovich AS.
    Journal: Biomed Biochim Acta; 1983; 42(5):471-7. PubMed ID: 6651799.
    Abstract:
    Binding of 125I-insulin to Ehrlich ascites carcinoma cells revealed the presence of high affinity binding sites characterized by a dissociation constant of 6.1 . 10(-9) M and a number of sites per cell of 2.6 . 10(3). These values are in line with respective data for other cell types reported in the literature. The receptor was identified by photoaffinity labeling of highly purified plasma membranes with 4-azido-benzoyl-125I-insulin as a probe. The only receptor protein detectable has a molecular mass of 120-122 kD. This finding is discussed in terms of metabolic and cell proliferation effects of insulin.
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