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  • Title: Parkinson's disease affects differently Met5- and Leu5-enkephalin in the human brain.
    Author: Taquet H, Javoy-Agid F, Hamon M, Legrand JC, Agid Y, Cesselin F.
    Journal: Brain Res; 1983 Dec 05; 280(2):379-82. PubMed ID: 6652499.
    Abstract:
    When measured in post-mortem human control brains, the ratio of Met5-enkephalin levels to those of Leu5-enkephalin varied from 1 to 13 in the 11 areas examined. In parkinsonian brains a significant reduction in the levels of both peptides was found in the pallidum and putamen whereas only Met5-enkephalin levels were decreased in the substantia nigra and ventral tegmental area. Therefore, Met5-enkephalin and Leu5-enkephalin may be located (at least partly) in different neuronal populations in the human brain.
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