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  • Title: [Skin necroses and ergotism after preventive administration of heparin-dihydroergotamine].
    Author: Jehn U, Clemm C, Ledderose G.
    Journal: Dtsch Med Wochenschr; 1983 Jul 29; 108(30):1148-50. PubMed ID: 6653417.
    Abstract:
    About 30 hours after prophylactic subcutaneous administration of heparin-dihydroergotamine to a 77-year-old man with generalized arteriosclerosis, extensive skin necroses developed at the injection sites and, after progressively increasing signs of mental disorientation, three days later there developed acute pulmonary oedema and a large ischaemic infarct of the median cerebral artery with hemiparesis and coma, which ended fatally. Skin necroses and ergotism are rare but serious complications of anticoagulant treatment.
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