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  • Title: [Experimental study of the antihypertensive activity of unithiol, D-penicillamine and cysteine].
    Author: Mashkovskiĭ MD, Shvarts GIa.
    Journal: Farmakol Toksikol; 1983; 46(6):24-8. PubMed ID: 6653753.
    Abstract:
    The thiol compounds, unithiol, D-penicillamine and cysteine administered per os, produce an antihypertensive effect in spontaneously hypertensive rats and in animals with experimental renovascular and DOCA-induced hypertension. The drugs reduce the pressor effect of angiotensin I and potentiate and prolong the depressor action of bradykinin in anesthetized normotensive rats. As for the activity unithiol and D-penicillamine are found to be superior to cysteine. This is in a good agreement with the drug inhibitory action in respect to dipeptidyl carboxypeptidase, an enzyme that plays the key role in the control of the activity of the renin-angiotensin and kallikrein-kinin systems of the body.
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