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  • Title: [Receptor binding of corticosterone in brain structures participating in regulation of the hypothalamo-hypophyseo-adrenal system].
    Author: Zhukov DA.
    Journal: Fiziol Zh SSSR Im I M Sechenova; 1983 Nov; 69(11):1463-6. PubMed ID: 6653828.
    Abstract:
    Binding of corticosterone by the cytosol receptors after hydrocortisone administration was studied in different tissues of rats. A decrease in the specific binding of corticosterone occurred within 24 hrs in all the structures under study. In 3 days the decrease only persisted in the hypophysis and hypothalamus. The data suggest a connection between the long lasting decrease in the cytosol reception of corticosterone in the hypothalamus and hypophysis and the blockade of the hypothalamo-hypophyseal-adrenal system.
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