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  • Title: [Protein synthesis following experimental injuries in the pig as disease model. Comparison of infusion solutions with various amino acid patterns].
    Author: Hartig W, Matkowitz R, Junghans P, Jung K, Faust H.
    Journal: Infusionsther Klin Ernahr; 1983 Oct; 10(5):276-9. PubMed ID: 6654496.
    Abstract:
    This study compares the effect of two amino acid solutions on protein metabolism after injury by measuring nitrogen balance, 15N-elimination, total body protein synthesis and utilisation of administered nitrogen in an experimental study using pigs. Protein synthesis and nitrogen utilisation were determined using a 15N-tracer technique with recourse to mathematical model concepts. The non-surgical control animals had a lower urinary nitrogen excretion, a more favourable nitrogen balance, a higher 15N-retention, greater total body protein synthesis and utilisation of the infused amino acids during infusion of an amino acid solution with a standard amino acid pattern (A) than the operated animals (solution B). Comparison of the post-operative data shows that if solution A is compared with solution B whose amino acid content takes account of changes in plasma amino acid metabolism following trauma, solution B yields the better results in respect of 15N-retention as well as total body protein synthesis and nitrogen utilisation.
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