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  • Title: Interaction between the macrophage system and IgA immune complexes in IgA nephropathy.
    Author: Roccatello D, Coppo R, Basolo B, Martina G, Rollino C, Cordonnier D, Busquet G, Picciotto G, Sena LM, Piccoli G.
    Journal: Proc Eur Dial Transplant Assoc; 1983; 20():610-6. PubMed ID: 6657680.
    Abstract:
    In nine patients with IgA nephropathy, the function of the mononuclear phagocyte system was assessed by measuring in vivo clearance of anti-D coated red blood cells (RBC) and in vitro phagocytosis of sensitised RBC by monocytes. A strict correlation was found between in vivo macrophage function and in vitro monocyte phagocytosis. Statistical correlations were also found between in vivo clearance values and IgAIC and C3d values. A defective macrophage and monocyte function affects patients with major signs of clinical activity, highest IgAIC values, signs of complement activation and the most unfavourable clinical course.
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