These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


Pubmed for Handhelds

PUBMED FOR HANDHELDS

Search MEDLINE/PubMed

  • Title: [Effect of novobiocin on degradation and repair of the superhelical structure of nuclear DNA from rat thymocyte fractions].
    Author: Vashchenko VI, Reshchikov AM, Komar VE, Khanson KP.
    Journal: Radiobiologiia; 1983; 23(6):786-9. PubMed ID: 6657941.
    Abstract:
    A study was made of the action of novobiocin on degradation and repair events in supercoiled nuclear DNA from three thymocyte fractions obtained by ficoll-paque gradient sedimentation. When added before gamma-irradiation novobiocin (1.9 mg/ml) exerted a radioprotective effect during the "second wave" of supercoiled DNA degradation. It is suggested that this effect may be due to the inhibition of DNA topoisomerase II.
    [Abstract] [Full Text] [Related] [New Search]