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  • Title: Effect of haloperidol and apomorphine treatment on dopamine receptors in pituitary and striatum.
    Author: Friend WC, Brown GM, Jawahir G, Lee T, Seeman P.
    Journal: Am J Psychiatry; 1978 Jul; 135(7):839-41. PubMed ID: 665797.
    Abstract:
    Prompted by an interest in the similarity of brain and tuberoinfundibular systems, the authors studied butaclamol-specific neuroleptic and apomorphine binding in pituitary and striatum after chronic haloperidol and acute apomorphine treatment. Striatal binding increases but pituitary binding decreases in haloperidol-treated rats. Pituitary binding changes rapidly in response to apomorphine exposure and striatal binding does not. These findings suggest that factors influencing binding differ in these two tissues.
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