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  • Title: Potassium load in spontaneously hypertensive rats. Effects on blood pressure, renin-angiotensin, aldosterone, and intracellular electrolytes.
    Author: Zidek W, Losse H, Schmidt W, Vetter H.
    Journal: Res Exp Med (Berl); 1983; 183(2):147-52. PubMed ID: 6658202.
    Abstract:
    To study the mechanisms by which K+ influences vascular tone in hypertension, spontaneously hypertensive and normotensive rats were examined during an oral K+ load. There was a marked decrease in blood pressure in spontaneously hypertensive but not in normotensive rats. Intraerythrocytic K+ concentration and activity increased in normotensive but not in spontaneously hypertensive rats. Intraerythrocytic Na+ concentration and activity declined in both strains, the decrease in Na+ activity being more prominent in spontaneously hypertensive rats (P less than 0.05). Intraerythrocytic Ca2+ activity decreased in spontaneously hypertensive rats (P less than 0.01) but not in normotensive rats. In both strains plasma aldosterone concentration increased during K+ load, the plasma renin activity being suppressed. The basal levels of plasma aldosterone in spontaneously hypertensive rats exceeded those in normotensive rats. It is concluded that intraerythrocytic Ca2+, and to a lesser extent Na+, correlate best with the blood pressure changes. These ionic changes may be mediated by hormonal factors. The significance of the elevated plasma aldosterone levels has not yet been entirely clarified.
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