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  • Title: Early effects of high-dosed absorbable amoscanate on rat brain.
    Author: Krinke G, Graepel P, Krueger L, Thomann P.
    Journal: Toxicol Lett; 1983 Dec; 19(3):261-6. PubMed ID: 6658839.
    Abstract:
    An oily suspension of the absorbable form of amoscanate was administered to young adult albino rats in single or repeated oral doses of 25, 125 and 500 mg/kg. At least 3 consecutive doses of 125 or 500 mg/kg were needed to induce a brain lesion. The early change consisted of necrosis of the ependyma of the lateral ventricles, indicating that intoxication may have occurred via the cerebrospinal fluid.
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