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  • Title: Phenytoin and folic acid: individualized drug-drug interaction.
    Author: Berg MJ, Rivey MP, Vern BA, Fischer LJ, Schottelius DD.
    Journal: Ther Drug Monit; 1983; 5(4):395-9. PubMed ID: 6659013.
    Abstract:
    The effect of folic acid supplementation on the disposition of phenytoin and the resultant loss of seizure control in a male folate-deficient epileptic is reported. Due to the increase in tonic-clonic seizures after the initiation of folic acid (1 mg, orally) the sodium phenytoin dosage was increased by 130 mg until control was achieved. Because of these dosage changes, the Vmax and Km were calculated before and after initiation of the folic acid. The Vmax remained relatively the same, but the Km decreased after folate supplementation.
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