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  • Title: [Analysis of cell lines obtained from tumors induced in Syrian hamsters by SA7 adenovirus and its DNA].
    Author: Tiunnikov TI, Ponomareva TI, Dreĭzin RS, Karmysheva VIa, Zolotarskaia EE.
    Journal: Vopr Virusol; 1983; 28(5):607-11. PubMed ID: 6659476.
    Abstract:
    Four cell lines derived from tumors induced by adenovirus SA7, its DNA (intact and fragmented with restrictase Sal-1), as well as isolated C-Sal-1 fragment (19.5% of genome) containing oncogene were studied. All the cell lines had the phenotypic markers of tumor cells, similar tumorigenicity, and produced T- and S-antigens. The line derived from the tumor induced by intact DNA contained the smallest adenovirus SA7 genome region (12%) which suggests that the information required for the synthesis of T and S antigens of adenovirus SA7 lies within the limits of this genome region.
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