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  • Title: Tissue distribution and elimination of [3H]levamisole in the rat after oral and intramuscular administration.
    Author: Galtier P, Coche Y, Alvinerie M.
    Journal: Xenobiotica; 1983 Jul; 13(7):407-13. PubMed ID: 6659543.
    Abstract:
    Total radioactivity and drug concentrations were determined in plasma, organs and excreta of male rats given a single oral or intramuscular dose (7.5 mg/kg) of [3H]levamisole. The anthelmintic drug was distributed mostly within the digestive contents after oral administration and in kidneys and liver after intramuscular injection. The parent drug accounted only for 32 to 45% of total radioactivity in plasma and it appeared metabolized in both urine and bile. The urine (0-72 h) contained 68-78% of the radioactive dose, as parent drug and other tritiated materials. The 4-hydroxylation of levamisole did not represent a major metabolic pathway of the drug in the rat.
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