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  • Title: Cerebral infarction improved by safflower treatment.
    Author: Kuang PG, Zhou XF, Zhang FY, Lang SY, Yang ZL.
    Journal: Am J Chin Med; 1983; 11(1-4):62-8. PubMed ID: 6660215.
    Abstract:
    The effect of safflower on cerebral infarction was studied in 152 Mongolian gerbils. Sixty-three animals were evaluated neurological deficit over 8 hours postoperation, then sacrificed and NE, DA and 5-HT contents of each cerebral hemisphere and brain stem were determined. NE, DA and 5-HT of hemisphere ipsilateral to the ligated artery in untreated animals declined significantly compared with sham-operated animals and safflower-treated gerbils. There was no significant difference between safflower-treated and sham-operated animals in NE, DA and 5-HT contents. The mean stroke index at 8 hours in safflower treated animals was 2.1 +/- 0.7, whereas untreated gerbils was 7.8 +/- 1.9 (P less than 0.01). Eighty-nine animals were followed up for 5 days, the safflower-treated animals showed a benign clinical course and mortality rate was reduced by 29.7% (6/34 vs. 26/55) in safflower-treated animals compared with untreated animals (P less than 0.01). Safflower has a protective and beneficial effect on cerebral ischemia induced in Mongolian gerbils.
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