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  • Title: The pig mesonephros. II. The proximal tubule: SEM, TEM and freeze-fracture images.
    Author: Tiedemann K, Zaar K.
    Journal: Anat Embryol (Berl); 1983; 168(2):241-52. PubMed ID: 6660564.
    Abstract:
    The ultrastructure of the proximal tubule of mature mesonephric nephrons was studied in perfusion-fixed pig embryos of the 41st gestational day. Despite its 8-12 mm long course, the proximal tubule possesses no cytologically different subsegments except its very last cells at the abrupt transition into the distal tubule. The first brush-bordered proximal tubule cells stand considerably within Bowman's capsule, abuting its attenuated cells. In SEM specimens, the average luminal cell diameters are 8 X 13 micron. The cells are 6-11 micron in height with overlying microvilli 2-4 micron long. Lateral faces of perfectly disjoined cells exhibit plate-like interdigitating processes projecting more than 5 micron deep into the neighboring cells. The basal cell face is completely covered with microvilli. The TEM pictures reveal an endocytic apparatus largely matching its metanephric counterpart. Mitochondria account for 23% of the cytoplasm and together with the many basolateral cell membranes indicate a high capacity for energy-dependent transport processes. Small basal lipid droplets represent a species peculiarity. Freeze-fracture specimens show an electrocoupling of the cells by gap junctions. The tight junction, with only 1-2 strands, characterizes a "leaky" epithelium. In most features, this tissue is as mature as its metanephric counterpart.
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