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  • Title: Hemin inhibits transfer of pre-delta-aminolevulinate synthase into chick embryo liver mitochondria.
    Author: Srivastava G, Borthwick IA, Brooker JD, Wallace JC, May BK, Elliott WH.
    Journal: Biochem Biophys Res Commun; 1983 Nov 30; 117(1):344-9. PubMed ID: 6661228.
    Abstract:
    Pulse labelling studies in chick embryo livers show that hemin prevents the transfer of drug induced pre-delta-aminolevulinate synthase from the cytosol into the mitochondria, leading to an accumulation of precursor in the cytosol. No effect of hemin was observed on the transfer of pre-pyruvate carboxylase into mitochondria. These results eliminated a general toxic effect of hemin on mitochondrial import of proteins and are consistent with the view that hemin specifically inhibits the transfer of ALA synthase.
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