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  • Title: Exercise-induced increments in plasma levels of propranolol and noradrenaline.
    Author: Hurwitz GA, Webb JG, Walle T, Bai SA, Daniell HB, Gourley L, Boyd Loadholt C, Gaffney TE.
    Journal: Br J Clin Pharmacol; 1983 Dec; 16(6):599-608. PubMed ID: 6661342.
    Abstract:
    Exercise-induced changes in the plasma levels of propranolol and noradrenaline were determined in nine volunteers. Total plasma propranolol levels were increased during submaximal treadmill exercise, with exercise-induced increments of 13 +/- 4% at 4 h after the last dose, 18 +/- 7% at 9 h and 41 +/- 5% at 16 h. Exercise-induced increments in plasma propranolol were observed after single as well as repeated doses. During exercise, increments in plasma propranolol were correlated temporally with changes in plasma noradrenaline. Exercise-induced increments in plasma noradrenaline were greater during propranolol administration than during placebo periods. The changes in plasma propranolol concentration during exercise may reflect a redistribution of propranolol at its site(s) of action.
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