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  • Title: [Peculiarities of nuclear genome transcription in the early stages of liver regeneration. Complex nature of the activating effect of the cytoplasmic regenerating factor on transcription in isolated rat liver nuclei].
    Author: Zheliabovskaia SM, Sverdel VP, Lebedeva LM, Bur'ianovskiĭ, Platonov OM.
    Journal: Biokhimiia; 1983 Nov; 48(11):1774-7. PubMed ID: 6661449.
    Abstract:
    The cytosol fractions from resting rat liver and from the liver 1 hour after partial hepatectomy which were not adsorbed on DEAE-cellulose were subjected to gel filtration with a view of elucidating the mechanism of its activating effect on the RNA-synthesizing ability of isolated nuclei of resting liver. The activating effect of this fraction is a complex one and includes both specific and non-specific factors. A subfraction typical for regenerating liver was detected, which activates RNA elongation in a synthesizing system with isolated nuclei of resting liver.
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