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  • Title: Analgesic effect of prolactin: possible mechanism of action.
    Author: Ramaswamy S, Pillai NP, Bapna JS.
    Journal: Eur J Pharmacol; 1983 Dec 09; 96(1-2):171-3. PubMed ID: 6662195.
    Abstract:
    The analgesic effect of prolactin (PRL) was tested by means of the acetic acid-induced writhing test and the hot plate method. In both assays PRL produced dose-dependent analgesia. This was antagonised by naltrexone indicating the involvement of opiate mechanisms. Bromocriptine, which inhibits PRL secretion through dopaminergic activity, also antagonised PRL-induced analgesia implicating dopaminergic mechanisms in this action of PRL. It is suggested that pituitary peptides may have a role in pain modulation along with the endogenous opioid peptides.
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