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  • Title: Inhibition of platelet function by sulbenicillin and its metabolite.
    Author: Ikeda Y, Kikuchi M, Matsuda S, Toyama K, Hasegawa M, Watanabe K, Ando Y.
    Journal: Antimicrob Agents Chemother; 1978 May; 13(5):881-3. PubMed ID: 666307.
    Abstract:
    The effect of sulbenicillin and its major metabolite, alpha-sulfobenzylpenicilloic acid, on platelet function was investigated. Sulbenicillin caused inhibition of platelet aggregation and release reaction in the same manner as carbenicillin. alpha-Sulfobenzylpenicilloic acid was found to cause much stronger inhibition of platelet function. The results indicate that the strong inhibitory action of alpha-sulfobenzylpenicilloic acid may also take part in impaired platelet functions following administration of sulbenicillin to humans.
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