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  • Title: Germ cell differentiation in mouse adrenal glands.
    Author: Zamboni L, Upadhyay S.
    Journal: J Exp Zool; 1983 Nov; 228(2):173-93. PubMed ID: 6663256.
    Abstract:
    The differentiation of germ cells in the adrenal glands of 26 male and female Swiss albino mice was studied in sequential stages of development, from day 12 1/2 of intrauterine life to postnatal day 21; the study was performed by means of high-resolution light microscopy and electron microscopy. In 12 1/2- and 13-day-old embryos, the ectopic cells had morphologic characteristics typical of primordial germ cells, whereas in 14- and 15-day-old fetuses they were identifiable as oogonia. In male and female fetuses from day 17 to term, all ectopic germinal elements entered meiotic prophase, reached diplotene, and differentiated into oocytes in perfect adherence to mouse ovarian timetables. In the postnatal animals, females as well as males, all oocytes progressed through the postmeiotic phase of growth just as they normally do in ovarian follicles, and, in the 2- and 3-week-old animals, they displayed features identical to those exhibited by oocytes in large antral follicles, including a zona pellucida. Germinal elements were no longer seen in the adrenals of animals older than 3 weeks. Our study shows that mammalian germ cells are capable of developing even outside the gonads, and that in ectopic sites they all differentiate as oocytes irrespective of their genetic sex.
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