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  • Title: Reduction in the local tissue toxicity of chlorpromazine by beta-cyclodextrin complexation.
    Author: Irie T, Kuwahara S, Otagiri M, Uekama K, Iwamasa T.
    Journal: J Pharmacobiodyn; 1983 Oct; 6(10):790-2. PubMed ID: 6663444.
    Abstract:
    Effect of beta-cyclodextrin (beta-CyD) on the local tissue toxicity of chlorpromazine (CPZ) was investigated following the intramuscular injection to rabbits. From the gross and histological examinations, beta-CyD was found to alleviate the muscular tissue damage produced by CPZ on M. vastus lateralis in rabbits. The protective effect of beta-CyD may be ascribed to the decrease in affinity of CPZ to the tissue membrane through inclusion complexation. The present data suggest that beta-CyD complexation is particularly useful to reduce the local toxicity of phenothiazine neuroleptics without altering the pharmacological efficacy.
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