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  • Title: Combined timolol and epinephrine therapy for open angle glaucoma.
    Author: Knupp JA, Shields MB, Mandell AI, Hurvitz L, Spaeth GL.
    Journal: Surv Ophthalmol; 1983 Dec; 28 Suppl():280-5. PubMed ID: 6665707.
    Abstract:
    A survey of the literature concerning the interaction of timolol and epinephrine in lowering intraocular pressure, and a study comparing the efficacy of timolol and dipivefrin (a prodrug of epinephrine) to that of timolol and pilocarpine are presented. These observations suggest that timolol-epinephrine therapy is less effective than timolol-pilocarpine treatment, although the former combination has clinical value in some patients, and it is possible that this can be enhanced when special schedules for drug administration are used.
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