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  • Title: Evidence that platelet alpha-granules are a major determinant of platelet density: studies in storage pool deficiency.
    Author: Vicic WJ, Weiss HJ.
    Journal: Thromb Haemost; 1983 Dec 30; 50(4):878-80. PubMed ID: 6665769.
    Abstract:
    Density-related subpopulations of platelets were obtained by centrifuging platelets obtained from venous blood on a discontinuous gradient of arabinogalactan (Stractan). Four subpopulations were obtained in fractions of the gradient with densities less than or equal to 1.058, 1.065, 1.070, and 1.092 g/ml. The percentage of the total platelet population recovered in these various fractions in 5 patients with congenital storage pool deficiency who are deficient only in dense granules (delta-SPD) was similar to that observed in 8 normal subjects. In contrast, a shift in the density distribution towards a higher percentage of less dense platelets was observed in 3 patients (alpha delta-SPD) who are deficient in both alpha and dense granules. The results of these studies strongly suggest that alpha-granules are a major determinant of platelet density.
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