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  • Title: [Blood amoxicillin concentrations in agricultural animals and poultry treated intramuscularly with drug forms containing amoxicillin sodium and amoxicillin trihydrate].
    Author: Lashev L, Drumev D.
    Journal: Vet Med Nauki; 1983; 20(9):96-105. PubMed ID: 6666035.
    Abstract:
    The sodium salts of ampicillin and amoxicillin at the single i/m application in 20 per cent water solutions at the rate of 10 mg per kg of body mass guaranteed close therapeutic concentrations of both antibiotics in the blood serum of birds and rabbits. Amoxicillin-trihydrate in a 20% water suspension applied i/m in a single dose of 10 mg/kg persisted in a therapeutic concentrations in the blood serum of birds for a longer time (10 hours) than ampicillin-trihydrate (8 hours). The oil suspension containing 20% amoxicillin-trihydrate guaranteed bacteriostatic serum concentrations in the course of 24 to 48 hours at single i/m application in doses of 20 and 30 mg/kg, depending on the amount and the species of animal. The optimal doses for calves and sheep were 20 mg/kg and 30 mg/kg injected at intervals of 24, resp., 48 hours, and for pigs and birds it were 30 mg/kg at 24-hour intervals. The choice of one or another dose depended on the sensitivity of the disease agents.
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