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  • Title: Hemodynamic measurements and exercise testing to assess the development of tolerance against slow-release isosorbide dinitrate.
    Author: Weidemann H, Schuon J, Schober B.
    Journal: Z Kardiol; 1983; 72 Suppl 3():229-32. PubMed ID: 6666226.
    Abstract:
    Hemodynamic measurements were carried out during exercise testing with floating catheterization in 12 male patients with multiple-vessel disease and stable angina pectoris after placebo, after acute treatment with 60 mg ISDN, and after 4 weeks treatment with 4 X 60 mg ISDN. The acute effects of ISDN at the maximal comparable workload were a 32% decrease in PAd, a 41% decrease in ST-segment depression, and a 35% increase in maximal workload. After 4 weeks therapy we found an attenuation of the efficacy of ISDN, with only a 12% decrease in PAd, a 33% decrease in ST-segment depression, and an 18% increase in maximal workload.
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