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  • Title: [Independence of the process of habituation from protein synthesis in the mollusk neuron].
    Author: Tsitolovskiĭ LE, Kukhanova MK.
    Journal: Zh Vyssh Nerv Deiat Im I P Pavlova; 1983; 33(6):1121-7. PubMed ID: 6666338.
    Abstract:
    The influence of protein synthesis blocators--puromicine and gougerotine--on the dynamics of habituation to repeated tactile stimuli in mollusc's neurones was studied microionophoretically. Dynamics of habituation was judged by reduction of impulses number in neurone's response, increase of thresholds and latency of the first synaptic action potential in the response to repeated stimuli. Introduction of the substances produced the greatest effect on the dynamics of thresholds. Puromicine introduction suppressed the habituation only if it was accompanied by generation of epileptiform activity. Gougerotine improved the habituation in the animals with initially weak process. The obtained data testify to the hypothesis that protein synthesis blockade does not impede the process of habituation.
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