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  • Title: Mutagenic and DNA damaging activity in muscle of trout exposed in vivo to nitrite.
    Author: De Flora S, Arillo A.
    Journal: Cancer Lett; 1983 Sep; 20(2):147-55. PubMed ID: 6667455.
    Abstract:
    Muscle ether extracts of rainbow trout (Salmo gairdneri) exposed to lake water enriched with nitrite (450 micrograms/l) reverted plasmid-containing his- strains of Salmonella typhimurium, mainly eliciting frameshift mutations, and induced a DNA damage in Escherichia coli reparable through the recA/lexA-dependent SOS functions. The number of revertants was related to their content in nitroso-derivatives and to the physiological condition of the fish. Mutagenicity was efficiently decreased, through NADPH-requiring pathways, by liver S-9 fractions from rats or rainbow trout, while it was not affected by preliminary heating nor by pre-incubation with human gastric juice.
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