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  • Title: Evoked cerebral potential correlates of C-fibre activity in man.
    Author: Bromm B, Neitzel H, Tecklenburg A, Treede RD.
    Journal: Neurosci Lett; 1983 Dec 23; 43(1):109-14. PubMed ID: 6669318.
    Abstract:
    CO2 laser emitted radiant heat pulses of 20 ms duration were used to activate predominantly slowly conducting nociceptive cutaneous afferents in man. Stimuli of two-fold individual pain threshold caused stinging and burning pain and elicited cerebral potentials with latencies consistent with A delta-fibre activity. After preferential block of the myelinated nerve fibres by pressure only the burning pain remained with significantly increased reaction time (about 1433 ms). The A delta-fibre-induced evoked potential components disappeared, and a marked ultralate positive component became visible with mean peak latency of 1260 ms, consistent with C-fibre activity.
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