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  • Title: Effect of L-tryptophan pretreatment on d-amphetamine self administration.
    Author: Lyness WH.
    Journal: Subst Alcohol Actions Misuse; 1983; 4(4):305-12. PubMed ID: 6670054.
    Abstract:
    Pretreatment with doses of the amino acid, L-tryptophan, known to increase brain serotonin levels, markedly reduced the number of intravenous self-injections of d-amphetamine in rats previously demonstrating stable self-administration patterns. This attenuation of response was dose dependent in both magnitude and duration. Pretreatment with L-tryptophan did not alter the response rate in animals trained on an FR-40 food reinforced paradigm. L-tryptophan administration did not alter the apparent turnover of dopamine in nucleus accumbens septi, important since manipulation of dopamine in this brain area exerts a marked influence on psychomotor stimulant self-administration. These results are consistent with previous reports suggesting a role of serotonergic neurons in the self-administration of d-amphetamine.
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