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  • Title: Stimulation of the Na+ pump by hypotonic solutions in skeletal muscle.
    Author: Venosa RA.
    Journal: Biochim Biophys Acta; 1978 Jul 04; 510(2):378-83. PubMed ID: 667052.
    Abstract:
    The fractional loss of 22 Na+ from frog sartorius muscle is increased when the tonicity of the external solution is reduced. The effect, which is larger the lower the osmolarity, exhibits the following characteristics: (1) quick onset and reversibility, (2) is not reduced in the absence of external Na+, (3) is completely abolished by strophanthidin (3. 10-5 M), (4) is neither the result of membrane depolarization nor K+ accumulation in the extracellular space.
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