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  • Title: [Content, intensity of exchange, and metabolic interaction of phospholipids and glycolipids in various tissues in experimental diabetes].
    Author: Saatov TS, Isaev EI, Ergashova MZh, Nikolaeva NF, Salikhodzhaeva DS.
    Journal: Biokhimiia; 1983 Dec; 48(12):1988-94. PubMed ID: 6671113.
    Abstract:
    The contents of individual gangliosides in various tissues (e. g. heart, skeletal muscles, liver, brain, kidney, spleen, pancreas) under normal conditions and in alloxan diabetes as well as the incorporation of 1-14C-stearate into the phospholipid, glyceride and total ganglioside fractions were studied. The oxidation of 14C-fatty acid and the activities of neuraminidase and lipase in these tissues were determined. It was found that diabetes is concomitant with a marked decrease of the content and exchange of gangliosides, which is paralleled with activation of neuraminidase. The incorporation of 14C-stearate in the sphingomyelin and phosphatidylcholine fractions is significantly decreased, while that in the cardiolipin fraction is increased 1.5 - 2-fold. The oxidation of 14C-stearate is also increased, the degree of this increase being tissue-specific.
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