These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


Pubmed for Handhelds

PUBMED FOR HANDHELDS

Search MEDLINE/PubMed

  • Title: Nuclear translocation of estradiol receptors by the in vivo administration of norethisterone: an alternate mechanism for gonadotropin inhibition.
    Author: Larrea F, Escobar N, Garza Flores J, Moctezuma O, Martínez-Campos A, Pérez-Palacios G.
    Journal: J Steroid Biochem; 1983 Dec; 19(6):1747-52. PubMed ID: 6672457.
    Abstract:
    In order to investigate the anti-gonadotropic effect of norethisterone (NET) in long-term ovariectomized rats, we studied the interaction of this synthetic progestin with intracellular steroid receptors in the anterior pituitary by a nuclear exchange assay. The results demonstrated that the administration of NET to long-term ovariectomized rats resulted in nuclear translocation of estradiol cytosol receptors in the pituitary and uterus with a rate of accumulation and nuclear retention being similar in both tissues. Accumulation of nuclear estradiol receptors in the pituitary was in agreement with the rate of LH inhibition in NET-treated rats. The results presented in this communication may explain the anti-gonadotropic activity of NET in long-term ovariectomized rats in addition to its well known progestational activity.
    [Abstract] [Full Text] [Related] [New Search]