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  • Title: Familial hypouricemia due to isolated renal tubular abnormality.
    Author: Benjamin D, Sperling O, Weinberg A, Pinkhas J.
    Journal: Biomedicine; 1978 Apr; 29(2):54-6. PubMed ID: 667288.
    Abstract:
    A family with genetic hypouricemia due to isolated renal tubular abnormality in urate handling is reported. Urinary urate excretion was decreased by 61% following administration of pyrazinamide, and increased by 25% following administration of probenecid. The response to these drug suggest genotype heterogeneity of renal hypouricemia in man.
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