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  • Title: [Changes in erythrocyte deformability following changes in oxido-reductive metabolism in diabetes mellitus].
    Author: Ghigo D, Bosia A, Pagani A, Pescarmona GP, Pagano G, Lenti G.
    Journal: Ric Clin Lab; 1983; 13 Suppl 3():375-81. PubMed ID: 6673017.
    Abstract:
    The enhanced sorbitol synthesis in diabetic red blood cells can lead to a depletion of NADPH and, by limiting the amount of GSH produced in the glutathione-reductase step, can make the cell more susceptible to oxidant injury. Diabetic red blood cells have a shortened life span, as shown by the increase of creatine level. The osmotic resistance of diabetic erythrocytes was measured and the erythrocyte flexibility was studied using a filtration method in which the cells were forced, at a constant flow rate, through a polycarbonate membrane with 5-mu pores. The increased osmotic resistance and the impaired flexibility shown by diabetic red blood cells can be induced in normal cells by a treatment with SH-reagents (diamide). This points to a redox state-mediated decrease in deformability and survival of diabetic erythrocytes.
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