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  • Title: Evidence of 2-hydroxylation of estradiol-17 beta 17-glucuronide by male rat liver microsomes.
    Author: Watanabe K, Yoshizawa I.
    Journal: Steroids; 1983 Aug; 42(2):163-70. PubMed ID: 6673185.
    Abstract:
    When estradiol-17 beta 17-glucuronide was incubated with male rat liver microsomal preparations with a NADPH-generating system, 2-hydroxyestradiol-17 beta 17-glucuronide was obtained. This 2-hydroxylation was shown to occur without cleavage of the conjugate group. The result clearly indicates that estradiol-17 beta 17-glucuronide could act as substrate for rat liver microsomal 2-hydroxylase.
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