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  • Title: [Protective effect of fosfomycin against renal accumulation of aminoglycoside antibiotics].
    Author: Fujita K, Fujita HM, Aso Y.
    Journal: Jpn J Antibiot; 1983 Dec; 36(12):3392-4. PubMed ID: 6674549.
    Abstract:
    Male Wistar rats received 20 mg/kg/day of amikacin (AMK) with or without 200 mg/kg/day of fosfomycin (FOM) for 5 days. Accumulation of AMK in renal lysosome-containing fraction was inhibited by FOM. FOM was reported to interfere with the nephrotoxic properties of aminoglycosides. Our observation supports the finding.
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