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  • Title: Mechanisms for activation and inhibition of carboxypeptidase A catalyzed hydrolyses of peptides and esters.
    Author: Sebastian JF, Lo WY.
    Journal: Can J Biochem; 1978 May; 56(5):329-33. PubMed ID: 667684.
    Abstract:
    3,3-Diphenylpropanoate (DPP) activates the carboxypeptidase A catalyzed hydrolysis of benzoylglycyl-L-phenylalanine (BzGly-L-Phe) (Ka = 2.1 x 10 (-3) M) and inhibits ester hydrolysis uncompetitively (K1 =2.1 X 10 (-3) M). A common modifier binding site located adjacent to the peptide and ester substrate binding sites is proposed. The forms of the pathways proposed for activation and inhibition are remarkably similar.
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