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Title: Acylated derivatives of 1,5-benzodiazepines. Author: Nawojski A, Nawrocka W, Liszkiewicz H. Journal: Pol J Pharmacol Pharm; 1983; 35(6):531-7. PubMed ID: 6677898. Abstract: N-Acylated derivatives of 2-methyl-2-ethoxycarbonyl-4-phenyl-1H-tetrahydro-1,5-benzodiazepine (1) and 2-cyano-4-methyl-1H-tetrahydro-1,5-benzodiazepine (3-12) were obtained. From among compounds 3-12, compound 3 have shown a strong synergism with hexobarbital and antiserotonin and anticonvulsant activity, and compounds 5 and 7 have displayed antiserotonin properties. A strong antireserpine action, comparable with imipramine, has been found for compound 12, which also have antagonized electrogenic seizures.[Abstract] [Full Text] [Related] [New Search]