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  • Title: Anti-spasmogenic effect of cyproheptadine on guinea-pig ileum.
    Author: Reylon V, Siddiqui HH.
    Journal: Indian J Physiol Pharmacol; 1983; 27(4):342-4. PubMed ID: 6678244.
    Abstract:
    Antagonistic activity of cyproheptadine against common spasmogens, like acetylcholine, histamine, serotonin, bradykinin and angiotensin, was studied on isolated guinea-pig ileum. Cyproheptadine produced a reversible antagonism of non-competitive type and was most effective against serotonin. It was less potent against histamine, bradykinin and angiotensin and least potent against acetylcholine.
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