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  • Title: Effect of exercise and guanethidine on plasma cholesterol and aortic atherosclerosis of atherogenic-fed cockerels.
    Author: Orimilikwe SO, Wong HY, David SN, Reinshagen JA.
    Journal: Artery; 1983; 12(1):60-73. PubMed ID: 6678579.
    Abstract:
    The effects of exercise (EX) and guanethidine (G) or its combination on plasma cholesterol and incidence and severity of aortic atherosclerosis of atherogenic-fed (AD) cockerels were studied. Eighty-five 16-week-old Hyline cockerels were subdivided as follows: I. Plain mash (PM); II. PM + EX; III. PM + G; IV. PM + EX + G; V. AD only; VI. AD + EX; VII. AD + G; and VIII. AD + EX + G. Birds ran approximately 500 yards for 20 minutes twice daily for twelve consecutive weeks. G (2.5 mg) was administered per os daily. The atherogenic diet consisted of 2% cholesterol + 5% cottonseed oil added to mash. At the end of 12 weeks the following results were obtained: 1) EX or G or its combination had no effect on plasma cholesterol of birds on PM. All AD-fed groups showed marked hypercholesterolemia as compared to their initial values. The AD + EX group had significantly lower plasma cholesterol level when compared to AD controls or AD + G group; 2) no gross aortic atherosclerosis was observed in cockerels on PM. The group on AD only had the most severe gross aortic atherosclerosis while the AD birds treated with G or EX + G had slightly lower aortic atheromatosis. This was in contrast to AD + EX group which showed a significant decrease in aortic atherogenesis. These results indicate that EX reduces plasma cholesterol and aortic atherosclerosis of AD birds while these effects of EX were negated by G.
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