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  • Title: A modified form of mitochondrial hexokinase produced by ATP-induced solubilization.
    Author: Ureta T, Radojković J, Bustamante E.
    Journal: Biochem Int; 1983 Nov; 7(5):585-92. PubMed ID: 6679748.
    Abstract:
    Mitochondrial hexokinases from several rat tissues were analyzed by DEAE-cellulose chromatography. Solubilization by glucose-6-P or Triton X-100 released hexokinases A and B. Solubilization by ATP resulted in a decrease of hexokinase A and the concomitant appearance of a new fraction of lower net charge (hexokinase Am) which readily reverts to hexokinase A by dialysis or dilution. Treatment of homogeneous or partially purified hexokinase A with ATP did not generate hexokinase Am. Hexokinases Am and A were equally inhibited by an anti-hexokinase immune serum and displayed the same Km values for glucose and ATP. Hexokinase Am may represent a conformer or an oligomer produced during ATP-induced solubilization of hexokinase A from mitochondria.
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