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  • Title: [Effect of opiates on Ca2+ transport in synaptosomes].
    Author: Zaĭtsev SV, Porodenko NV, Varfolomeev SD.
    Journal: Bioorg Khim; 1983 Jun; 9(6):849-51. PubMed ID: 6679785.
    Abstract:
    Potassium-stimulated uptake of Ca2+ by nerve-ending fractions from rat brain (synaptosomes) is inhibited by morphine and [D-Ala2, D-Leu5]enkephalin. This effect develops significantly within 1 minute. The opiates do not affect the Ca2+ efflux from the synaptosomes. Naloxone, the opiate antagonist, does not reverse the effect of morphine on synaptosomal Ca2+ uptake, and in this respect itself acts similarly to morphine).
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