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  • Title: Muscle transketolase in normal foetuses and Duchenne dystrophy.
    Author: Banerji AP, Karandikar PV, Varadkar AM, Desai AD, Potnis AV.
    Journal: Clin Chim Acta; 1978 Jun 15; 86(3):307-11. PubMed ID: 668121.
    Abstract:
    The activity of the enzyme transketolase (EC 2.2.1.1) or the pentose phosphate metabolizing enzyme (PPME) was investigated in the quadriceps muscles of patients with Duchenne muscular dystrophy (DMD), polymyositis and spinal muscular atrophy (SMA) and in normal foetuses. The enzyme activity was significantly elevated in these muscle disorders with highest and lowest levels seen in DMD and SMA groups, respectively. The enzyme activity was increased early in DMD muscle and appeared to increase with progression of the disease. Normal foetal muscle contained high transketolase activity which is comparable to that seen in DMD patients.
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