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  • Title: Freeze-fracture analysis of plasma membrane cholesterol in Duchenne muscle.
    Author: Fischbeck KH, Bonilla E, Schotland DL.
    Journal: Ann Neurol; 1983 May; 13(5):532-5. PubMed ID: 6681514.
    Abstract:
    We estimated cholesterol in Duchenne muscle plasma membrane using the sterol-specific ligand digitonin. In measuring the extent of digitonin-cholesterol complex formation with freeze-fracture electron microscopy, we found a significantly greater proportion of surface area taken up by complexes in Duchenne muscle (60% +/- 9%) than in controls (36% +/- 4%). This finding suggests that a population of Duchenne muscle fibers has a higher concentration of cholesterol in the plasma membrane. Membrane cholesterol is known to affect membrane deformability and the activity of membrane-bound enzymes and transport proteins; thus a difference in membrane cholesterol might account for structural and functional abnormalities in Duchenne plasma membrane.
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