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  • Title: Intra-blood-brain barrier measles virus antibody synthesis in multiple sclerosis patients.
    Author: Albrecht P, Tourtellotte WW, Hicks JT, Sato H, Boone EJ, Potvin AR.
    Journal: Neurology; 1983 Jan; 33(1):45-50. PubMed ID: 6681559.
    Abstract:
    Antibodies to nine viruses were measured in serum and CSF of MS patients, patients with other neurologic diseases (OND), and healthy controls. The extent of antibody production inside the blood-brain barrier (BBB) was determined by making a new correction for BBB permeability. Compared with OND and healthy controls, MS patients as a group had significantly higher corrected CSF:serum antibody ratios for measles virus but not to the other eight viruses studied. The incidence of significantly high CSF:serum ratios for measles antibody in MS patients was 50%, and in the other two control groups it was 0 to 12%. The incidence of corrected antibody ratios to the other eight viruses was not significantly different among the three groups.
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